References

USDA AWA Regulations And Standards – Proposed Use Of Animals

From the USDA Animal Welfare Act Regulations and Standards: 
“(d) IACUC review of activities involving animals. (1) In order to approve proposed activities or proposed significant changes in ongoing activities, the IACUC shall conduct a review of those components of the activities related to the care and use of animals and determine that the proposed activities are in accordance with this subchapter unless acceptable justification for a departure is presented in writing; Provided, however, that field studies as defined in part 1 of this subchapter are exempt from this requirement. Further, the IACUC shall determine that the proposed activities or significant changes in ongoing activities meet the following requirements:…” 
http://www.access.gpo.gov/nara/cfr/waisidx/9cfr2.html