From PHS Policy, section IV.C.1.g:
“C. Review of PHS-Conducted or Supported Research Projects In order to approve proposed research projects or proposed significant changes in ongoing research projects, the IACUC shall conduct a review of those components related to the care and use of animals and determine that the proposed research projects are in accordance with this Policy. In making this determination, the IACUC shall confirm that the research project will be conducted in accordance with the Animal Welfare Act insofar as it applies to the research project, and that the research project is consistent with the Guide unless acceptable justification for a departure is presented. 8 Further, the IACUC shall determine that the research project conforms with the institution’s Assurance and meets the following requirements:
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g. Methods of euthanasia used will be consistent with the recommendations of the AVMA Guidelines on Euthanasia, unless a deviation is justified for scientific reasons in writing by the investigator.”